Ọgwụ Cialis. ntuziaka maka ojiji

Ọgwụ Cialis. ntuziaka maka ojiji

2 - blisters (1) - ngwugwu kaadiboodu.

Njirimara

Ihe na-arụ ọrụ Tadalafil

Ụdị mwepụta1 - ọnya (1) - ngwugwu kaadiboodu.
2 - blisters (4) - ngwugwu kaadiboodu.

Obodo nrụpụta Puerto Rico/Spain

Emepụtara ya bụ Lilly del Caribe Inc/Lilly S.A.

Zere ụmụaka

Ụdị usoro onunu ogwu

Mbadamba mbadamba ihe nkiri na-acha odo odo, almond, nke ejiri "C20" mee ihe n'otu akụkụ

Ngwakọta

tadalafil 20 mg

Ihe mgbakwunye: lactose monohydrate, hyprolose (hydroxypropylcellulose), croscarmellose sodium, microcrystalline cellulose, magnesium stearate, sodium lauryl sulfate.

Ngwakọta nke shei ihe nkiri: Opadry II odo - lactose monohydrate, hypromellose, titanium dioxide, triacetin, iron dye yellow oxide.

Otu ọgwụ ọgwụ

ọgwụgwọ adịghị arụ ọrụ erectile - PDE5 inhibitor

Pharmacodynamics

Ọgwụ maka ọgwụgwọ erectile dysfunction. Ọ bụ onye na-emechi nhọrọ nhọrọ nke ụdị phosphodiesterase 5 (PDE5) cGMP. Mgbe mkpali mmekọahụ na-akpata ntọhapụ mpaghara nke nitric oxide, nkwụsị PDE5 site na tadalafil na-ebute mmụba nke ọkwa cGMP na corpus cavernosum nke amụ. Ihe si na ya pụta bụ izu ike nke akwara dị nro nke akwara na mgbaba ọbara na anụ ahụ nke amụ, nke na-eme ka ọkpụkpụ. Tadalafil enweghị mmetụta ọ bụla na enweghị mkpali mmekọahụ.

Nnyocha ọmụmụ vitro egosila na tadalafil bụ onye na-emechi PDE5 na-ahọrọ. PDE5 bụ enzyme a na-achọta n'ime akwara dị nro nke anụ ahụ dị nro, na akwara dị nro nke arịa nke akụkụ ahụ, na akwara skeletal, platelet, akụrụ, akpa ume na cerebellum.

Mmetụta nke tadalafil na PDE5 na-arụ ọrụ karịa na phosphodiesterases ndị ọzọ. Tadalafil bụ 10,000 ugboro na-arụsi ọrụ ike megide PDE5 karịa megide PDE1, PDE2, PDE4, PDE7, nke dị n'ime obi, ụbụrụ, arịa ọbara, imeju, leukocytes, skeletal muscle na akụkụ ndị ọzọ. Tadalafil bụ 10,000 ugboro na-arụsi ọrụ ike na igbochi PDE5 karịa PDE3, enzyme dị n'ime obi na arịa ọbara. Nhọrọ a maka PDE5 n'elu PDE3 dị mkpa n'ihi na PDE3 bụ enzyme na-etinye aka na nkwonkwo akwara obi. Tụkwasị na nke ahụ, tadalafil dị ihe dịka 700 ugboro karịa PDE5 karịa PDE6, nke dị na retina ma na-ahụ maka fototransmission.

Tadalafil nwekwara 9,000 ugboro ike na PDE5 karịa mmetụta ya na PDE8, 9 na 10 ugboro na 14 ugboro karịa PDE5 karịa PDE11. Ekepụtabeghị nkesa anụ ahụ na mmetụta physiological nke mgbochi PDE8-PDE11.

Tadalafil na-emeziwanye nrụpụta na ohere nke inwe mmekọahụ na-aga nke ọma.

Ọgwụ ahụ na-arụ ọrụ maka awa 36. Mmetụta a na-egosi ugbua 16 nkeji mgbe ọ ṅụsịrị ọgwụ ahụ n'ihu agụụ mmekọahụ.

Tadalafil n'ime ndị ahụ dị mma adịghị ebute mgbanwe dị ukwuu na systolic na ọbara mgbali elu diastolic, ma e jiri ya tụnyere placebo, n'ọnọdụ dị elu (nkezi mbelata ọbara mgbali elu bụ 1.6 / 0.8 mm Hg, n'otu n'otu) na guzo (nkezi kachasị mbelata na ọbara mgbali elu bụ 0.2/4.6 mm Hg .st n'otu n'otu). Tadalafil anaghị eme mgbanwe dị ukwuu na ọnụọgụ obi.

Tadalafil anaghị eme mgbanwe na njirimara agba (acha anụnụ anụnụ / akwụkwọ ndụ akwụkwọ ndụ), nke a kọwara site na mmekọrịta dị ala maka PDE6. Tụkwasị na nke ahụ, ọ dịghị mmetụta nke tadalafil na-ahụ anya, electroretinogram, nrụgide intraocular na nha ụmụ akwụkwọ.

Emeela ọtụtụ ọmụmụ iji nyochaa mmetụta tadalfil kwa ụbọchị na spermatogenesis. Enweghị mmetụta ọjọọ na sperm morphology na motility hụrụ n'ime ọmụmụ ihe ọ bụla. Otu nnyocha chọpụtara mbelata n'ọnụ ọgụgụ spam ma e jiri ya tụnyere placebo. Mbelata nke mkpokọta spam na-ejikọta ya na ọnụ ọgụgụ dị elu nke ejaculation. Na mgbakwunye, tadalafil emeghị mgbanwe na-adịghị mma na ọdịnaya nke testosterone, LH na FSH na plasma ọbara, ma e jiri ya tụnyere placebo.

Pharmacokinetics

Mmanya

Mgbe nchịkwa ọnụ gasịrị, tadalafil na-abanye ngwa ngwa. A na-enweta Cmax mgbe nkezi nke awa 2 gasịrị. Ọnụego na ogo nke absorption anaghị adabere na nri nri. Oge ị na-aṅụ ọgwụ ahụ (ututu ma ọ bụ mgbede) enweghị mmetụta dị ịrịba ama na ọnụọgụ na oke nke absorption.

Pharmacokinetics nke tadalafil n'ime ndị mmadụ nwere ahụike bụ akara n'ihe gbasara oge na dose. N'ime usoro onunu ogwu sitere na 2.5 ruo 20 mg AUC na-abawanye n'oke nha nha. A na-enweta Css na plasma n'ime ụbọchị 5 mgbe ị na-aṅụ ọgwụ 1 oge /

Ngwọta ọgwụ nke tadalafil na ndị na-arịa ọrịa na-adịghị erectile yiri nke pharmacokinetics nke ọgwụ na ndị mmadụ na-enweghị arụ ọrụ erectile.

Nkesa

Nkezi Vd bụ ihe dị ka lita 63, nke na-egosi na a na-ekesa tadalafil na anụ ahụ. Na mkpokọta ọgwụgwọ, 94% nke tadalafil na-ejikọ na protein plasma. N'ime ndị ahụ siri ike, a na-ahụ ihe na-erughị 0.0005% nke ọgwụ a na-enye na semen.

Metabolism

A na-eme ya metabolized tumadi site na ntinye aka nke CYP3A4 isoenzyme. Isi metabolite na-ekesa bụ methylcatecholglucuronide. Ọ bụ 13,000 ugboro obere arụ ọrụ megide PDE5 karịa tadalafil. Ya mere, metabolite a agaghị adị mkpa na ụlọ ọgwụ.

ozuzu

N'ime ndị nwere ahụike, nkezi mkpochapụ nke tadalafil mgbe a na-ekwu okwu bụ 2.5 l / h, na nkezi T1 / 2 bụ awa 17.5. Tadalafil na-apụkarị dị ka metabolites na-adịghị arụ ọrụ, tumadi na feces (ihe dị ka 61%) na n'ókè dị nta. mmamịrị (ihe dịka 36%).

Pharmacokinetics na ọnọdụ ụlọ ọgwụ pụrụ iche

N'ime ndị agadi nwere ahụike (afọ 65 na karịa), a na-ekpebi nkwụsịtụ nke tadalafil dị ala, nke a na-egosipụta na mmụba na AUC site na 25% ma e jiri ya tụnyere ndị nwere ahụike dị afọ 19 ruo 45. Ọdịiche a abụghị ihe dị mkpa na ụlọ ọgwụ na ọ chọghị mmezi dose.

N'ime ndị ọrịa nwere ụkọ akụrụ, gụnyere ndị ọrịa na-anata hemodialysis, AUC dị ukwuu karịa ndị nwere ahụike. Njikọ protein anaghị agbanwe site na arụrụ arụ ọrụ gbasara akụrụ.

Pharmacokinetics nke tadalafil na ndị ọrịa nwere obere imeju afọ ma ọ bụ na-agafeghị oke dị ka nke ahụ na ndị nwere ahụike. Enweghị data dị maka ndị ọrịa nwere oke ịba ọcha n'anya (Klas Child-Pugh C).

N'ime ndị ọrịa na-arịa ọrịa shuga na-agwọta tadalafil, AUC dị ihe dịka 19% erughị ndị nwere ahụike. Ọdịiche a anaghị achọ mgbanwe dose.

Ngosipụta

arụrụ arụ erectile (ED);

obere mgbaàmà urinary tract na ndị ọrịa nwere hyperplasia prostate benign;

arụrụ arụ erectile n'ime ndị ọrịa nwere mgbaàmà urinary ala ala jikọtara ya na hyperplasia prostate benign.

Contraindications

- n'out oge nchịkwa nke ọgwụ nwere ihe ọ bụla organic nitrates;

- eji na ndị nọ n'okpuru afọ 18;

- Hypersensitivity na akụkụ nke ọgwụ.

Usoro onunu ogwu na nchịkwa

A na-aṅụ ọgwụ ahụ n'ọnụ, n'agbanyeghị nri.

Oke kachasị akwadoro nke Cialis® bụ 20 mg. Oge nnabata kacha akwadoro bụ oge 1 /

A na-ewere Cialis® opekata mpe nkeji iri na isii tupu emee mmekọ nwoke na nwanyị.

Ndị ọrịa nwere ike ịnwale inwe mmekọahụ n'oge ọ bụla n'ime awa 36 ka ha were ọgwụ ahụ iji wepụta oge nzaghachi kachasị mma na ọgwụ ahụ.

Mmetụta

Ọtụtụ mgbe: isi ọwụwa (11%), dyspepsia (7%).

Mmetụta dị n'akụkụ na-adịkarị nwayọọ ma ọ bụ agafeghị oke n'ịdị njọ, na-adịru nwa oge na mbelata na iji ọgwụ ahụ na-aga n'ihu.

O kwere omume: mgbu azụ, myalgia, dizziness, imi imi, ịmịcha ihu.

Ọ na-adịkarịghị: ọzịza nke nku anya, mgbu anya, hyperemia conjunctival.

Ọ dị obere: mmeghachi omume hypersensitivity (gụnyere rashes, urticaria na ọzịza nke ihu, ọrịa Stevens-Johnson na exfoliative dermatitis); hypotension arterial (n'ime ndị ọrịa ewerela ọgwụ antihypertensive), ọbara mgbali elu na syncope; mgbu afọ na gastroesophageal reflux; hyperhidrosis (ọsụsọ dị ukwuu); priapism na igbu oge ere; Ọhụụ na-adịghị ahụkebe, ischemic optic neuropathy na-abụghị arterial, vein vein occlusion, ọgba aghara a na-ahụ anya, migraine, epistaxis.

N'ime ndị ọrịa nwere ihe ize ndụ nke obi: myocardial infarction, ọnwụ cardiogenic mberede, ọrịa strok, mgbu obi, palpitations, tachycardia. Otú ọ dị, ọ gaghị ekwe omume ikpebi nke ọma ma ihe omume ndị a metụtara kpọmkwem ihe ndị a dị ize ndụ, na tadalafil, na-akpali agụụ mmekọahụ, ma ọ bụ na-ejikọta ihe ndị a ma ọ bụ ihe ndị ọzọ.

Ịṅụbiga mmanya ókè

Site n'otu oge nye ndị ọrụ afọ ofufo ahụike na dose nke 500 mg / ụbọchị yana ndị ọrịa nwere nsogbu erectile - ugboro ugboro ruo 100 mg / ụbọchị, mmetụta ndị na-adịghị mma bụ otu ihe ahụ mgbe ị na-eji ọgwụ ahụ na obere doses.

mmekọrịta ọgwụ ọjọọ

Mmetụta ọgwụ ndị ọzọ na tadalafil

Tadalafil bụ metabolized site na CYP3A4 enzyme. Onye na-egbochi CYP3A4 ketoconazole na dose nke 400 mg / ụbọchị na-abawanye AUC nke tadalafil n'otu dose site na 312% yana Cmax site na 22% na ketoconazole na dose nke 200 mg / ụbọchị na-abawanye mkpughe nke tadalafil. Otu dose site na 107% na Cmax site na 25%, metụtara ụkpụrụ AUC na Cmax maka naanị otu tadalafil.

Ritonavir (200 mg 2), onye na-egbochi CYP3A4, 2C9, 2C19 na 2D6, na-abawanye AUC nke tadalfil n'otu dose site na 524% na-agbanweghị Cmax. Ọ bụ ezie na a mụọbeghị mkparịta ụka kpọmkwem, enwere ike iche na ndị ọzọ na-egbochi nje protease HIV, dị ka saquinavir, yana CYP3A4 inhibitors, dị ka erythromycin na itraconazole, na-abawanye ọrụ nke tadalafil.

Nhọrọ nke CYP3A4, rifampicin (rifampicin, 600 / mg /), na-ebelata AUC nke otu dose tadalafil site na 88% na Cmax site na 46%, n'ihe metụtara ụkpụrụ AUC na Cmax maka tadalafil naanị.

ntụziaka pụrụ iche

Site na ịkpachara anya, ekwesịrị ịnye ọgwụ ahụ maka ndị ọrịa nwere oke ịba ọcha n'anya (klas Child-Pugh C), ebe data sitere na ọmụmụ ụlọ ọgwụ a na-achịkwa na nchekwa na ịdị mma nke Cialis na ụdị ndị ọrịa adịghị.

Achọrọ ịkpachara anya mgbe ị na-edepụta Cialis® na ndị ọrịa na-ewere alpha1-blockers, dị ka doxazosin, ebe ọ bụ na iji otu oge eme ihe n'ọnọdụ ụfọdụ nwere ike ibute hypotension arterial symptomatic. N'ime ọmụmụ ọgwụ ọgwụ na ụlọ ọgwụ na ndị ọrụ afọ ofufo 18 nwere ahụike bụ ndị were otu dose nke tadalafil, a hụghị hypotension arterial symptomatic na nchịkwa nke alpha1-blocker tamsulosin n'otu oge.

Mmekọahụ nwere ihe ize ndụ maka ndị ọrịa nwere ọrịa obi. Ya mere, ọgwụgwọ nke nrụrụ erectile, gụnyere. N'iji ọgwụ Cialis® eme ihe n'ime ụmụ nwoke nwere ọnọdụ obi nke anaghị akwado mmekọahụ.

Ekwesịrị iburu n'uche ihe ize ndụ nke ịmepụta nsogbu n'oge mmekọ nwoke na nwanyị na-arịa ọrịa nke usoro obi: myocardial infarction n'ime ụbọchị 90 ikpeazụ; angina ma ọ bụ angina na-adịgide adịgide nke na-eme n'oge mmekọahụ; nkụda mmụọ obi na-adịghị ala ala (klas na-arụ ọrụ II na n'elu dị ka nhazi NYHA) nke mepụtara n'ime ọnwa isii gara aga; ọgba aghara ọgba aghara obi na-achịkwaghị achịkwa; hypotension arterial (BP na-erughị 90/50 mm Hg) ma ọ bụ ọbara mgbali elu na-achịkwaghị achịkwa; ọrịa strok n'ime ọnwa isii gara aga.

Ekwesịrị iji Cialis jiri nlezianya mee ihe na ndị ọrịa nwere nnukwu ụkọ akụrụngwa siri ike (CC ihe na-erughị 30 ml / min), na-enwekwa ụkọ akụrụ na-agafeghị oke (CC site na 31 ruo 50 ml / min), n'ime ndị ọrịa nwere ebumnuche priapism (dịka ọmụmaatụ, nwere sickle). -cellular anaemia, multiple myeloma ma ọ bụ leukemia) ma ọ bụ na ndị ọrịa nwere nrụrụ anatomical nke amụ (dịka ọmụmaatụ, na angulation, cavernous fibrosis, ma ọ bụ ọrịa Peyronie).

Enwere akụkọ banyere ihe omume nke priapism na iji PDE5 inhibitors, gụnyere tadalfil. Ekwesịrị ịgwa onye ọrịa ahụ mkpa ọ dị maka nlekọta ahụike ozugbo ma ọ bụrụ na ere ọkụ na-ewe awa 4 ma ọ bụ karịa. Ọgwụgwọ na-adịghị ahụkebe nke priapism na-eduga na mmebi nke anụ ahụ nke amụ, n'ihi nke a na-enwe ike ịnwụ ogologo oge.

Amụbeghị nchekwa na ịdị irè nke nchikota Cialis® na ọgwụgwọ ndị ọzọ maka arụrụ arụ erectile. Ya mere, a naghị atụ aro iji ngwakọta ndị dị otú ahụ.

Dị ka ndị ọzọ PDE5 inhibitors, tadalafil nwere usoro vasodilating Njirimara, nke nwere ike iduga mbelata ọbara mgbali elu.

Ọnọdụ nchekwa

2 ℃ ruo 25 ℃

2 - blisters (2) - ngwugwu kaadiboodu.

reg. Nọmba: LP-000133

Tab., mkpuchi ihe nkiri kpuchie, 5 mg: 14 ma ọ bụ 28 pcs.

site na 11.01.11
Cialis ®

 

Mbadamba ụrọ na- acha odo odo, nke yiri almond, ihe nkiri, nke a kanyere "C 5" n'otu akụkụ.

Ndị na-enye aka : lactose monohydrate - 109.65 mg, lactose monohydrate (gbasa akpọnwụ) - 17.50 mg, hyprolose - 1.22 mg, hyprolose (extra thin) - 2.80 mg, sodium lauryl sulfate - 0.49 mg, microcrystalline cellulose.25 mg. , magnesium stearate (akwukwo nri) - 0.88 mg.

Ngwakọta nke shei ihe nkiri: opadry odo (Y-30-12863-A) - 8.75 mg (lactose monohydrate - 3.72 mg, hypromellose - 2.59 mg, titanium dioxide - 1.54 mg, triacetin - 0.74 mg, ígwè agba odo oxide - 0.16). mg).

14 pcs. - ọnya (1) - ngwugwu kaadiboodu.
14 pcs. - ọnya (2) - ngwugwu kaadiboodu.

Ụbọchị emelitere: 25.05.2020

A na-atụ aro ka ndị ikom na-emepe emepe ka ha were dose nke 20 mg ma ọ dịkarịa ala 16 nkeji tupu omume mmekọahụ na-atụ anya, n'agbanyeghị nri. Ndị ọrịa nwere ike ịnwale inwe mmekọahụ n'oge ọ bụla n'ime awa 36 mgbe ha risịrị nri iji guzobe oge nzaghachi kacha mma na tadalafil. Oke kacha nke nnabata bụ 1 oge / ụbọchị.

nchịkwa nke otu oge nke ọgwụ nwere ihe ọ bụla organic nitrates; ụmụaka na ndị nọ n'afọ iri na ụma ruo afọ 18; hypersensitivity na tadalafil.

site na 05.03.09
Cialis ®

 

Mbadamba ụrọ, ihe nkiri na-acha odo odo, nke yiri almond, nke nwere aha "C 20" n'otu akụkụ.

Ndị na-enye aka : lactose monohydrate - 245.195 mg, hyprolose (hydroxypropylcellulose) - 8.05 mg, croscarmellose sodium - 22.4 mg, microcrystalline cellulose - 52.5 mg, magnesium stearate - 0.875 mg, sodium - 8 mg lauryl.

Ngwakọta nke shei ihe nkiri: Opadry II odo (lactose monohydrate, hypromellose, titanium dioxide, triacetin, iron oxide yellow dye) - 14 mg.

1 PC. - ọnya (1) - ngwugwu kaadiboodu.
2 pcs. - ọnya (1) - ngwugwu kaadiboodu.
2 pcs. - ọnya (2) - ngwugwu kaadiboodu.
2 pcs. - ọnya (4) - ngwugwu kaadiboodu.

Cialis® _

Site na ịkpachara anya na naanị n'ọnọdụ mberede, ọ ga-ekwe omume iji tadalafil na ndị ọrịa nwere nnukwu ụkọ akụrụngwa (CC ≤ 30 ml / min) na imeju imeju.

N'oge ọgwụgwọ na tadalafil, ndị ọrịa na-arịa ọrịa akụrụ na-agafeghị oke (CC site na 31 ruo 50 ml / min) nwere ike ịnweta mgbu azụ ma e jiri ya tụnyere ndị ọrịa nwere obere renal insufficiency (CC si 51 ruo 80 ml / min) ma ọ bụ ndị ọrụ afọ ofufo dị mma. Na ndị ọrịa nwere CC≤50 ml / min, tadalafil kwesịrị iji nlezianya mee ihe.

Ya mere, ọgwụgwọ nke nrụrụ erectile, gụnyere. na ojiji nke tadalafil ekwesịghị ime na ndị ikom nwere ọnọdụ obi nke a naghị atụ aro mmekọahụ.

Ekwesịrị iburu n'uche ihe ize ndụ nke ịmepụta nsogbu n'oge mmekọ nwoke na nwanyị na-arịa ọrịa nke usoro obi: myocardial infarction n'ime ụbọchị 90 ikpeazụ; angina ma ọ bụ angina na-adịgide adịgide nke na-eme n'oge mmekọahụ; nkụda mmụọ obi na-adịghị ala ala (klas na-arụ ọrụ II na n'elu dị ka nhazi NYHA) nke mepụtara n'ime ọnwa isii gara aga; ọgba aghara ọgba aghara obi na-achịkwaghị achịkwa; hypotension arterial (BP na-erughị 90/50 mm Hg) ma ọ bụ ọbara mgbali elu na-achịkwaghị achịkwa; ọrịa strok n'ime ọnwa isii gara aga.

Ekwesịrị iji Tadalafil jiri nlezianya mee ihe na ndị ọrịa nwere ihe na-ebute priapism (dịka ọmụmaatụ, na-arịa ọrịa sickle cell anaemia, multiple myeloma ma ọ bụ leukemia) ma ọ bụ na ndị ọrịa nwere nrụrụ anatomical nke amụ (dịka ọmụmaatụ, na angulation, cavernous fibrosis ma ọ bụ ọrịa Peyronie).

Ekwesịrị ịgwa onye ọrịa ahụ mkpa ọ dị maka nlekọta ahụike ozugbo ma ọ bụrụ na ere ọkụ na-ewe awa 4 ma ọ bụ karịa. Ọgwụgwọ na-adịghị ahụkebe nke priapism na-eduga na mmebi nke anụ ahụ nke amụ, n'ihi nke a na-enwe ike ịnwụ ogologo oge.

N'ihe banyere ndabere nke iji tadalafil eme ihe, ọ dịghị ihe gbasara priapism a kọrọ.

A naghị atụ aro ka iji tadalafil jikọtara ya na ọgwụgwọ ndị ọzọ maka arụrụ arụ erectile.

💊Ngwakọta nke ọgwụ Cialis ®

Cialis ®
(Cialis ® )
Cialis ®

Onye na-ahụ maka ọgwụgwọ nke dysfunction erectile, bụ onye na-emechi nhọrọ nke PDE5 cGMP kpọmkwem. Mgbe mkpali mmekọahụ na-akpata ntọhapụ mpaghara nke nitric oxide, nkwụsị PDE5 site na tadalafil na-ebute mmụba nke ọkwa cGMP na corpus cavernosum nke amụ. Ihe si na ya pụta bụ izu ike nke akwara dị nro nke akwara na mgbaba ọbara na anụ ahụ nke amụ, nke na-eme ka ọkpụkpụ. Tadalafil adịghị arụ ọrụ na enweghị mkpali mmekọahụ.

Nnyocha ọmụmụ vitro egosila na tadalafil bụ onye na-emechi PDE5 na-ahọrọ. PDE5 bụ enzyme a na-achọta n'ime akwara dị nro nke anụ ahụ dị nro, na akwara dị nro nke arịa nke akụkụ ahụ, na akwara skeletal, platelet, akụrụ, akpa ume na cerebellum.

Mmetụta nke tadalafil na PDE5 na-arụ ọrụ karịa na phosphodiesterases ndị ọzọ. Tadalafil bụ 10,000 ugboro na-arụsi ọrụ ike megide PDE5 karịa megide PDE1, PDE2, PDE4, nke dị n'ime obi, ụbụrụ, arịa ọbara, imeju na akụkụ ndị ọzọ. Tadalafil bụ 10,000 ugboro na-arụsi ọrụ ike na igbochi PDE5 karịa PDE3, enzyme dị n'ime obi na arịa ọbara. Nhọrọ a maka PDE5 n'elu PDE3 dị mkpa n'ihi na PDE3 bụ enzyme na-etinye aka na nkwonkwo akwara obi. Tụkwasị na nke ahụ, tadalafil dị ihe dịka 700 ugboro karịa PDE5 karịa PDE6, nke dị na retina ma na-ahụ maka fototransmission. Tadalafil bụkwa 10,000 ugboro na-arụsi ọrụ ike megide PDE5 karịa mmetụta ya na PDE7-PDE10.

Ọ na-eme ihe n'ime awa 36. Mmetụta a na-apụta ugbua 16 nkeji mgbe ọ risịrị nri n'ihu agụụ mmekọahụ.

Tadalafil na ndị nwere ahụike anaghị ebute mgbanwe dị ukwuu na systolic na nrụgide diastolic, ma e jiri ya tụnyere placebo na ọnọdụ dị mfe (nkezi mbelata bụ 1.6 / 0.8 mm Hg, n'otu n'otu) na guzo (nkezi mbelata bụ 0.2 / 4.6 mm Hg). .otu n'otu). Tadalafil anaghị eme mgbanwe dị ukwuu na ọnụọgụ obi.

Tadalafil anaghị eme mgbanwe na njirimara agba (acha anụnụ anụnụ / akwụkwọ ndụ akwụkwọ ndụ), nke a kọwara site na mmekọrịta dị ala maka PDE6. Tụkwasị na nke ahụ, ọ dịghị mmetụta nke tadalafil na-ahụ anya, electroretinogram, nrụgide intraocular na nha ụmụ akwụkwọ.

Enweghị mmetụta dị mkpa na ụlọ ọgwụ na njirimara spam na ndị ikom na-ewere tadalafil kwa ụbọchị maka ọnwa 6.

Ọtụtụ mgbe: isi ọwụwa, dyspepsia.

O kwere omume: mgbu azụ, myalgia, imi imi, ịmịcha ihu.

Ọ na- adịkarịghị: ọzịza nke nku anya, mgbu anya, hyperemia conjunctival, dizziness.

Site na ịkpachara anya na naanị n'ọnọdụ mberede, ọ ga-ekwe omume iji tadalfil na ndị ọrịa nwere nnukwu ụkọ akụrụngwa (CC ≤ 30 ml / min).

N'ihe banyere ndabere nke ọgwụgwọ na tadalfil, ndị ọrịa nwere oke renal insufficiency (CC sitere na 31 ruo 50 ml / min) nwere ike nweta mgbu azụ ma e jiri ya tụnyere ndị ọrịa nwere obere renal insufficiency (CC si 51 ruo 80 ml / min) ma ọ bụ ndị ọrụ afọ ofufo dị mma. . N'ime ndị ọrịa nwere CC ≤50 ml / min, tadalfil kwesịrị iji nlezianya mee ihe.

A naghị eji ọgwụ ahụ eme ihe na ụmụ nwanyị.

Mgbe nchịkwa ọnụ gasịrị, tadalafil na-abanye ngwa ngwa. A na-enweta C max mgbe nkezi nke awa 2. Ọnụ ọgụgụ na ogo nke absorption anaghị adabere na nri nri. Pharmacokinetics nke tadalafil n'ime ndị mmadụ nwere ahụike bụ akara n'ihe gbasara oge na dose. N'ime usoro onunu ogwu sitere na 2.5 ruo 20 mg AUC na-abawanye n'ogo nke dose ahụ. A na-enweta C ss na plasma n'ime ụbọchị 5 mgbe ị na-aṅụ ọgwụ 1 oge / ụbọchị.

Ngwọta ọgwụ nke tadalafil na ndị na-arịa ọrịa na-adịghị erectile yiri nke pharmacokinetics nke ọgwụ na ndị mmadụ na-enweghị arụ ọrụ erectile.

V d bụ ​​ihe dị ka lita 63, nke na-egosi na tadalafil na-ekesa na anụ ahụ. Na mkpokọta ọgwụgwọ, 94% nke tadalafil na-ejikọ na protein plasma. N'ime ndị ahụ siri ike, a na-ahụ ihe na-erughị 0.0005% nke ọgwụ a na-enye na semen.

A na-eme ya metabolized site na ntinye aka nke CYP3A4 isoenzyme. Isi metabolite na-ekesa bụ methylcatecholglucuronide, nke dị 13,000 ugboro na-adịchaghị ike megide PDE5 karịa tadalafil, yabụ na metabolite a agaghị adị mkpa na ụlọ ọgwụ.

N'ime ndị nwere ahụike, nkezi mkpochapụ nke tadalafil bụ 2.5 l / h, na nkezi ọkara ndụ bụ awa 17.5. Tadalafil na-apụkarị dị ka metabolites na-adịghị arụ ọrụ, tumadi na feces (ihe dị ka 61%) na n'ókè dị nta na mmamịrị (ihe dị ka 61%). ihe dịka 36%).

N'ime ndị ọrịa nwere ụkọ akụrụ dị nro (CC sitere na 51 ruo 80 ml / min) ma ọ bụ ịdị oke oke (CC sitere na 31 ruo 50 ml / min), AUC dị ukwuu karịa ndị nwere ahụike.

✅Ojiji nke ọgwụ Cialis ®

Cialis ® (Cialis ® )
reg. Mba: P N014761 / 01
Site na ịkpachara anya na naanị na mberede, ọ ga-ekwe omume iji tadalfil na ndị ọrịa nwere oke ịba ọcha n'anya.

Tab., mkpuchi ihe nkiri kpuchie, 20 mg: 1, 2, 4 ma ọ bụ 8 pcs.

Tadalafil bụ metabolized site na CYP3A4 enzyme. Nhọrọ nke CYP3A4 inhibitor ketoconazole na-abawanye AUC site na 107%, ebe rifampicin na-ebelata ya site na 88%.

Ọ bụ ezie na amụbeghị mmekọrịta dị iche iche, enwere ike iche na ndị na-egbochi protease dị ka ritonavir na saquinavir, yana CYP3A4 inhibitors dị ka erythromycin na itraconazole, na-abawanye ọrụ nke tadalafil.

Mgbe ị na-ewere antacid (magnesium hydroxide / aluminum hydroxide) na tadalafil, ọnụego nnabata nke ikpeazụ na-ebelata na-agbanweghị AUC ya.

Tadalafil na-akwalite mmetụta hypotensive nke nitrates. Nke a na-eme n'ihi ntinye mgbakwunye nke nitrates na tadalafil na nitric oxide na cGMP metabolism. Ya mere, ojiji nke tadalafil na ndị ọrịa na-anata nitrates bụ contraindicated.

Nsogbu mmewere.

Site na ịkpachara anya na naanị n'ọnọdụ mberede, ọ ga-ekwe omume iji tadalafil na ndị ọrịa nwere nnukwu ụkọ akụrụngwa (CC ≤ 30 ml / min) na imeju imeju. N'oge ọgwụgwọ na tadalafil, ndị ọrịa na-arịa ọrịa akụrụ na-agafeghị oke (CC site na 31 ruo 50 ml / min) nwere ike ịnweta mgbu azụ ma e jiri ya tụnyere ndị ọrịa nwere obere renal insufficiency (CC si 51 ruo 80 ml / min) ma ọ bụ ndị ọrụ afọ ofufo dị mma. Na ndị ọrịa nwere CC≤50 ml / min, tadalafil kwesịrị iji nlezianya mee ihe. Ya mere, ọgwụgwọ nke nrụrụ erectile, gụnyere. na ojiji nke tadalafil ekwesịghị ime na ndị ikom nwere ọnọdụ obi nke a naghị atụ aro mmekọahụ. Ekwesịrị iburu n'uche ihe ize ndụ nke ịmepụta nsogbu n'oge mmekọ nwoke na nwanyị na-arịa ọrịa nke usoro obi: myocardial infarction n'ime ụbọchị 90 ikpeazụ; angina ma ọ bụ angina na-adịgide adịgide nke na-eme n'oge mmekọahụ; nkụda mmụọ obi na-adịghị ala ala (klas na-arụ ọrụ II na n'elu dị ka nhazi NYHA) nke mepụtara n'ime ọnwa isii gara aga; ọgba aghara ọgba aghara obi na-achịkwaghị achịkwa; hypotension arterial (BP na-erughị 90/50 mm Hg) ma ọ bụ ọbara mgbali elu na-achịkwaghị achịkwa; ọrịa strok n'ime ọnwa isii gara aga. Ekwesịrị iji Tadalafil jiri nlezianya mee ihe na ndị ọrịa nwere ihe na-ebute priapism (dịka ọmụmaatụ, sickle cell anaemia, multiple myeloma, ma ọ bụ leukemia) ma ọ bụ na ndị ọrịa nwere nrụrụ anatomical nke amụ (dịka ọmụmaatụ, angulation, fibrosis cavernous ma ọ bụ ọrịa Peyronie). Ekwesịrị ịgwa onye ọrịa ahụ mkpa ọ dị maka nlekọta ahụike ozugbo ma ọ bụrụ na ere ọkụ na-ewe awa 4 ma ọ bụ karịa. Ọgwụgwọ na-adịghị ahụkebe nke priapism na-eduga na mmebi nke anụ ahụ nke amụ, n'ihi nke a na-enwe ike ịnwụ ogologo oge. N'ihe banyere ndabere nke iji tadalafil eme ihe, ọ dịghị ihe gbasara priapism a kọrọ. A naghị atụ aro ka iji tadalafil jikọtara ya na ọgwụgwọ ndị ọzọ maka arụrụ arụ erectile. N'ihe banyere ndabere nke iji tadalafil eme ihe, ọ dịghị ihe gbasara priapism a kọrọ. A naghị atụ aro ka iji tadalafil jikọtara ya na ọgwụgwọ ndị ọzọ maka arụrụ arụ erectile. N'ihe banyere ndabere nke iji tadalafil eme ihe, ọ dịghị ihe gbasara priapism a kọrọ. A naghị atụ aro ka iji tadalafil jikọtara ya na ọgwụgwọ ndị ọzọ maka arụrụ arụ erectile.

Tadalafil bụ metabolized site na CYP3A4 enzyme. Nhọrọ nke CYP3A4 inhibitor ketoconazole na-abawanye AUC site na 107%, ebe rifampicin na-ebelata ya site na 88%. Ọ bụ ezie na amụbeghị mmekọrịta dị iche iche, enwere ike iche na ndị na-egbochi protease dị ka ritonavir na saquinavir, yana CYP3A4 inhibitors dị ka erythromycin na itraconazole, na-abawanye ọrụ nke tadalafil. Mgbe ị na-ewere antacid (magnesium hydroxide / aluminum hydroxide) na tadalafil, ọnụego nnabata nke ikpeazụ na-ebelata na-agbanweghị AUC ya. Tadalafil na-akwalite mmetụta hypotensive nke nitrates. Nke a na-eme n'ihi ntinye mgbakwunye nke nitrates na tadalafil na nitric oxide na cGMP metabolism. Ya mere, ojiji nke tadalafil na ndị ọrịa na-anata nitrates bụ contraindicated.

A naghị eji ọgwụ ahụ eme ihe na ụmụ nwanyị

nchịkwa nke otu oge nke ọgwụ nwere ihe ọ bụla organic nitrates; ụmụaka na ndị nọ n'afọ iri na ụma ruo afọ 18; hypersensitivity na tadalafil

nsogbu erection

Mgbaàmà: na otu nhọpụta nke tadalafil maka ndị nwere ahụike na dose nke ihe ruru 500 mg yana ndị ọrịa nwere arụ ọrụ erectile - ugboro ugboro ruo 100 mg / ụbọchị, mmetụta ndị na-adịghị mma bụ otu ihe ahụ mgbe ị na-eji ọgwụ ahụ na obere doses. Ọgwụgwọ: ọ bụrụ na ịdoụbiga mmanya ókè, a ga-eme ọgwụgwọ Symptomatic ọkọlọtọ. Site na hemodialysis, tadalafil anaghị apụ apụ.

Ọtụtụ mgbe: isi ọwụwa, dyspepsia. O kwere omume: mgbu azụ, myalgia, imi imi, ịmịcha ihu. Na-adịghị ahụkebe: edema nkuchianaya, anya mgbu, conjunctival hyperemia, dizziness

n'ime. Ojiji nke Cialis maka nrụrụ erectile (ED). Maka ndị ọrịa na-enwe mmekọahụ ugboro ugboro (karịa ugboro 2 n'izu): oge ​​nchịkwa a na-atụ aro bụ kwa ụbọchị, 1 oge kwa ụbọchị, 5 mg, n'otu oge, n'agbanyeghị nri oriri. Enwere ike ibelata dose ahụ kwa ụbọchị ruo 2.5 mg, dabere na uche onye ọ bụla. Maka ndị ọrịa na-enwekarị mmekọahụ (ihe na-erughị ugboro 2 n'izu): a na-atụ aro ka ị nye iwu Cialis na dose nke 20 mg ozugbo tupu mmekọahụ, dị ka ntuziaka maka ọgwụgwọ ọgwụ. Oke kachasị kwa ụbọchị nke Cialis bụ 20 mg. Iji Cialis maka BPH ma ọ bụ ED/BPH. Usoro akwadoro nke Cialis mgbe ejiri ya otu ugboro n'ụbọchị bụ 5 mg; a ga-ewere ọgwụ ahụ n'ihe dịka otu oge n'ụbọchị, n'agbanyeghị oge mmekọahụ. Ogologo oge ọgwụgwọ na-ekpebi dọkịta n'otu n'otu. N'ime ndị ọrịa nwere ụkọ akụrụ dị nro (Cl creatinine sitere na 51 ruo 80 ml / min) yana agafeghị oke (Cl creatinine sitere na 31 ruo 50 ml / min), a chọghị mmezi dose. N'ime ndị ọrịa nwere nnukwu ụkọ gbasara akụrụ (Cl creatinine <30 ml / min yana na hemodialysis): A machibidoro iji Cialis.

Na-emeziwanye ọrụ erectile

Ngwọta ọgwụ nke tadalafil na ndị na-arịa ọrịa na-adịghị erectile yiri nke pharmacokinetics nke ọgwụ na ndị mmadụ na-enweghị arụ ọrụ erectile. Absorption Tadalafil na-abanye ngwa ngwa mgbe nchịkwa ọnụ gasịrị. A na-enweta nkezi Cmax na plasma na nkezi awa 2 ka ejirichara ya. Ọnụ ọgụgụ na ogo nke absorption nke tadalafil adịghị adabere na nri nri, ya mere enwere ike iji Cialis mee ihe n'agbanyeghị nri oriri. Oge nchịkwa (ututu ma ọ bụ mgbede) enweghị mmetụta dị ukwuu na ụlọ ọgwụ na ọnụego na oke nke absorption. Pharmacokinetics nke tadalafil n'ime ndị mmadụ nwere ahụike bụ akara n'ihe gbasara oge na dose. N'ime usoro onunu ogwu sitere na 2.5 ruo 20 mg AUC na-abawanye n'ogo nke dose ahụ. A na-enweta nkesa Css na plasma n'ime ụbọchị 5 mgbe ị na-aṅụ ọgwụ 1 oge / ụbọchị. Nkezi Vd bụ ihe dị ka lita 63, nke na-egosi na a na-ekesa tadalafil na anụ ahụ. Njikọ protein Plasma nke tadalafil na mkpokọta ọgwụgwọ bụ 94%. N'ime ndị ahụ siri ike, a na-ahụ ihe na-erughị 0.0005% nke ọgwụ a na-enye na semen. Metabolism Tadalafil bụ metabolized nke ọma site na ntinye nke CYP3A4 isoenzyme. Isi metabolite na-ekesa bụ methylcatecholglucuronide. Metabolite a dịkarịa ala ugboro 13,000 adịghị arụ ọrụ megide PDE5 karịa tadalafil. Ya mere, itinye uche nke metabolite a abụghị ihe dị mkpa na ụlọ ọgwụ. Mwepụ N'ime ndị nwere ahụike, nkezi mkpochapụ nke tadalafil mgbe a na-ekwu ya bụ 2.5 l / h, na nkezi T1 / 2 bụ awa 17.5. Tadalafil na-apụkarị n'ụdị metabolites na-adịghị arụ ọrụ, tumadi na feces (ihe dị ka 61% nke dose ahụ). ) na, ruo n'ókè dị nta, na mmamịrị (ihe dịka 36% nke dose). Pharmacokinetics na ọnọdụ ụlọ ọgwụ pụrụ iche Njikọta protein anaghị agbanwe site na arụrụ arụ ọrụ gbasara akụrụ. Ndị ọrịa agadi nwere ahụike (65 afọ na karịa) nwere nkwụsị ọnụ nke tadalafil dị ala, nke e gosipụtara na 25% na-abawanye na AUC ma e jiri ya tụnyere ndị nwere ahụike dị afọ 19 ruo 45. Ọdịiche a abụghị ihe dị mkpa na ụlọ ọgwụ na ọ chọghị mmezi dose. N'ime ndị ọrịa nwere ụkọ akụrụ dị obere ma ọ bụ agafeghị oke, a chọghị mmezi dose. N'ihi ụbara mkpughe nke tadalafil (AUC), a naghị atụ aro ndị ọrịa nwere nnukwu ụkọ akụrụ ka ha jiri Cialis. Pharmacokinetics nke tadalafil na ndị ọrịa nwere obere imeju imeju na-adịghị ala ala dị ka nke ahụ na ndị nwere ahụike. Enweghị data dị maka ndị ọrịa nwere oke ịba ọcha n'anya (Klas Child-Pugh C). Mgbe ị na-edepụta Cialis na ndị ọrịa nwere oke ịba ọcha n'anya, ọ dị mkpa ibu ụzọ nyochaa ihe egwu na uru dị na iji ọgwụ ahụ. N'ime ndị ọrịa na-arịa ọrịa shuga na-agwọta tadalafil, AUC dị ihe dịka 19% erughị ndị nwere ahụike. Ọdịiche a anaghị achọ mmezi dose.

Ihe na-arụ ọrụ: tadalafil. ihe mgbakwunye: lactose monohydrate - 109.65 mg; lactose monohydrate (fesa akpọnwụwo) - 17.5 mg; giprolose - 1.22 mg; hyprolose ọzọ mkpa - 2.8 mg; sodium lauryl sulfate - 0.49 mg; MCC - 26.25 mg; sodium croscarmellose - 11.2 mg; magnesium stearate (akwukwo nri) - 0.88 mg. Shei ihe nkiri: Opadry odo (Y-30-12863-A) (lactose monohydrate - 3.72 mg, hypromellose - 2.59 mg, titanium dioxide - 1.54 mg, triacetin - 0.74 mg, iron dye yellow oxide - 0.16 mg) - 8.75 m


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