Fluconazole - ntuziaka maka ojiji

Fluconazole - ntuziaka maka ojiji

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Njirimara

Ihe na-arụ ọrụ Fluconazole

Hapụ ụdị Capsules 150 mg - 4 iberibe kwa mkpọ.

Obodo nrụpụta Russia

Onye nrụpụta OZON PHARM LLC

Zere ụmụaka

Ụdị usoro onunu ogwu

Capsules gelatin siri ike Nke 2. Ahụ na okpu bụ ìhè edo edo, opaque. Ihe dị n'ime capsules bụ ntụ ntụ ma ọ bụ ngwakọta nke ntụ ntụ na granules nke agba ọcha ma ọ bụ na-acha ọcha nwere ntakịrị tint na-acha odo odo. A na-ahapụ ya ka ọ mechie ihe dị n'ime capsule dịka ọdịdị nke capsule si dị, na-agbasa mgbe a pịa ya.

Ngwakọta

Ihe na-arụ ọrụ: fluconazole - 150.00 mg.

Ndị enyemaka: lactose monohydrate (shuga mmiri ara ehi) - 58.49 mg, starch pregelatinized 18.98 mg, colloidal silicon dioxide - 0.23 mg, magnesium stearate - 2.07 mg, sodium lauryl sulfate - 0.23 mg.

Ngwakọta nke capsule 150 mg:

Capsule ahụ: titanium dioxide - 2.0%, iron agba odo oxide - 0.1%, gelatin - ruo 100%.

Capsule okpu: titanium dioxide - 2.0%, iron agba odo oxide - 0.1%, gelatin - ruo 100%.

Otu ọgwụ ọgwụ

antifungal gị n'ụlọnga

Pharmacodynamics

Fluconazole, onye na-ahụ maka antifungal triazole, bụ ihe na-egbochi ike nke sterol njikọ na cell fungal.

Fluconazole egosila ọrụ in vitro na ọrịa na-agwọ ọrịa megide ọtụtụ n'ime microorganisms ndị a: Candida albicans, Candida glabrata (ọtụtụ ụdị na-enwe mmetụta dị nro), Candida parapsilosis, Candida tropicalis, Cryptococcus neoformans.

E gosiputara Fluconazole ka ọ na-arụ ọrụ na vitro megide microorganisms ndị a, mana amabeghị ihe ọ pụtara na ụlọ ọgwụ: Candida dubliniensis, Candida guilliermondii, Candida kefyr, Candida lusitaniae.

Mgbe a na-enye ya ọnụ, fluconazole na-arụ ọrụ n'ụdị dị iche iche nke ọrịa fungal na anụmanụ. Ọrụ nke ọgwụ na opportunistic mycoses, incl. Ihe kpatara Candida spp. (gụnyere candidiasis n'ozuzu na anụmanụ ndị na-egbochi ọrịa), Cryptococcus neoformans (gụnyere ọrịa intracranial), Microsporum spp. na Trychophyton spp. E guzobewokwa ọrụ nke fluconazole n'ụdị mycoses endemic na anụmanụ, gụnyere ọrịa nke Blastomyces dermatitides kpatara, Coccidioides immitis (gụnyere ọrịa intracranial) na Histoplasma capsulatum n'ime anụmanụ nwere ihe mgbochi nkịtị na nke na-egbochi.

Fluconazole nwere nkọwa dị elu maka enzymes fungal dabere na cytochrome P450. Ọgwụgwọ na fluconazole na dose nke 50 mg / ụbọchị ruo ụbọchị 28 anaghị emetụta mkpokọta testosterone na plasma ọbara n'ime ụmụ nwoke ma ọ bụ itinye uche nke steroid na ụmụ nwanyị na-amụ nwa. Fluconazole na dose nke 200-400 mg / ụbọchị enweghị mmetụta dị ịrịba ama na ụlọ ọgwụ na ọkwa steroid endogenous na nzaghachi ha na mkpali adrenocorticotropic hormone (ACTH) na ndị ọrụ afọ ofufo dị mma.

Usoro mmepe nke iguzogide fluconazole

Nguzogide fluconazole nwere ike ịmalite n'ọnọdụ ndị a: mgbanwe nke qualitative ma ọ bụ ọnụọgụ na enzyme nke bụ ebumnuche nke fluconazole (lanosteril 14-alpha-demethylase), mbelata ohere ịnweta ebumnuche nke fluconazole, ma ọ bụ ngwakọta nke usoro ndị a.

Mgbanwe nrụtụ aka na mkpụrụ ndụ ihe nketa ERG11 na-edobere enzyme ebumnuche na-eduga na ngbanwe nke ebumnuche yana mbelata mmekọrịta nke azoles. Mmụba na ngosipụta nke mkpụrụ ndụ ERG11 na-eduga n'ịmepụta mkpokọta dị elu nke enzyme ebumnuche, nke na-eme ka ọ dị mkpa ịbawanye mkpokọta fluconazole na mmiri intracellular iji gbochie ụmụ irighiri enzyme niile dị na cell.

Usoro nke abụọ dị ịrịba ama nke nguzogide bụ mwepụ nke fluconazole na-arụ ọrụ site na oghere intracellular site na ịgbalite ụdị ndị na-ebu ibu abụọ na-etinye aka na mwepụ (efflux) nke ọgwụ sitere na cell fungal. Ndị njem dị otú ahụ na-agụnye ozi bụ isi nke mkpụrụ ndụ ihe nketa MDR (ọtụtụ ọgwụ na-eguzogide ọgwụ) na ezinụlọ karịrị nke ATP na-ejikọta cassette nke ndị na-ebu njem nke mkpụrụ ndụ ihe nketa CDR (genes na-eguzogide candida na azole antimycotics).

Mkpesa nke mkpụrụ ndụ ihe nketa MDR na-eduga n'iguzogide fluconazole, ebe oke okwu nke mkpụrụ ndụ ihe nketa CDR nwere ike ibute iguzogide azoles dị iche iche. Nguzogide Candida glabrata na-abụkarị onye ogbugbo site n'ịkwupụta oke nke mkpụrụ ndụ CDR, na-ebute iguzogide ọtụtụ azoles. Maka ụdị ahụ nke akọwara ntanye inhibitory kacha nta (MIC) dị ka nke etiti (16-32 μg / ml), a na-atụ aro ka iji ọgwụ kachasị nke fluconazole.

Candida krusei kwesịrị ka a na-ewere na ọ na-eguzogide ọgwụ fluconazole. Ejikọtara usoro nguzogide ya na mbelata mmetụta nke enzyme ebumnuche na mmetụta mgbochi nke fluconazole.

Pharmacokinetics

Pharmacokinetics nke fluconazole yiri mgbe a na-enye ya n'ime intravenously na ọnụ. Mgbe nchịkwa ọnụ gasịrị, fluconazole na-etinye uche nke ọma, ntinye ya na plasma (na mkpokọta bioavailability) karịrị 90% nke ndị ahụ mgbe a na-enye ya n'ime intravenous. Iri nri n'otu oge anaghị emetụta nnabata nke fluconazole. Ntinye uche nke Plasma dabara na dose ahụ wee rute kacha (Cmax) 0.5-1.5 awa mgbe ị were fluconazole na afo efu, na ọkara ndụ (T1 / 2) bụ ihe dị ka awa 30. 90% nke ịta nha nha ruru site na. ụbọchị nke anọ ma ọ bụ nke ise mgbe mmalite ọgwụgwọ (na ọtụtụ doses nke ọgwụ 1 oge kwa ụbọchị). Oke kachasị nke fluconazole na asu mgbe ị na-ewere capsule na-eru mgbe awa 4 gachara.

Iwebata dose a na-ebu ibu (n'ụbọchị nke mbụ), ugboro abụọ a na-emebu kwa ụbọchị, na-eme ka o kwe omume iji nweta 90% nke nha nha n'ụbọchị nke abụọ. Olu nkesa na-eru nso mkpokọta mmiri dị n'ime ahụ. Njikọ protein Plasma dị obere (11-12%).

Fluconazole na-abanye nke ọma n'ime mmiri ahụ niile. Ọnụnọ nke Fluconazole na saliva na sputum yiri nke dị na plasma. N'ime ndị ọrịa nwere meningitis fungal, mkpokọta fluconazole na mmiri cerebrospinal bụ ihe dịka 80% nke mkpokọta plasma ya.

Na stratum corneum, epidermis, dermis na ọsụsọ mmiri, a na-enweta ihe dị elu karịa ọkwa ọbara. Fluconazole na-agbakọta na stratum corneum.

Mgbe ewere ya na 50 mg otu ugboro kwa ụbọchị, ịta nke fluconazole mgbe ụbọchị iri na abụọ gachara bụ 73 mcg / g, na mgbe ụbọchị 7 gachara ọgwụgwọ - naanị 5.8 mcg / g. Mgbe ejiri ya na 150 mg otu ugboro n'izu, ntinye nke fluconazole na stratum corneum n'ụbọchị nke asaa bụ 23.4 mcg / g na ụbọchị 7 mgbe usoro nke abụọ gasịrị - 7.1 mcg / g. Ntinye nke fluconazole na mbọ mgbe ọnwa 4 gachara na dose nke 150 mg 1 oge kwa izu bụ 4.05 μg / g na ahụike yana 1.8 μg / g na mbọ emetụtara; Ọnwa 6 ka emechara ọgwụgwọ, a ka na-ekpebi fluconazole na mbọ. A na-ewepụ ọgwụ a tumadi site na akụrụ: ihe dịka 80% nke ọgwụ a na-enye ka a na-ahụ na mmamịrị agbanweghị. Mwepụ nke Fluconazole dabara na mkpochapụ creatinine. Ahụghị metabolites na-ekesa.

Ogologo oge T1 / 2 sitere na plasma ọbara na-enye gị ohere ị were fluconazole otu ugboro maka candidiasis ikpu na 1 oge kwa ụbọchị ma ọ bụ 1 oge kwa izu maka ihe ngosi ndị ọzọ. Pharmacokinetics na ụmụaka

N'ime ụmụaka, a na-enweta ụkpụrụ ndị a nke pharmacokinetic:

Ogologo oge ọkara ndụ (awa) Mpaghara n'okpuru usoro oge itinye uche (AUC) (mcg-h/ml)

Ọnwa 9 - afọ 13 Otu dose - ọnụ 2 mg/kg 25.0 94.7

Ọnwa 9 - afọ 13 Otu dose - ọnụ 8 mg/kg 19.5 362.5

Ọkara afọ 7 Ọtụtụ ọnụọgụ ọnụ 3 mg/kg 15.5 41.6

Pharmacokinetics na ndị agadi agadi

Achọpụtara na site na otu dose nke fluconazole na dose 50 mg ọnụ na ndị agadi agadi 65 afọ na karịa, ụfọdụ n'ime ha na-aṅụ diuretics n'otu oge, Cmax ruru awa 1.3 mgbe nchịkwa gasịrị ma bụrụ 1.54 μg / ml, nkezi ụkpụrụ. AUC - 76.4 ± 20.3 μg-h / ml, na nkezi 1 / n - awa 46.2. Ụkpụrụ nke pharmacokinetic paramita ndị a dị elu karịa ndị ọrịa na-eto eto, nke nwere ike ịbụ n'ihi mbelata ọrụ gbasara akụrụ nke ndị agadi. Nri diuretics n'otu oge emeghị mgbanwe pụtara ìhè na AUC na Cmax.

Nwepu Creatinine (74 ml / min), pasent nke fluconazole nke akụrụ na-agbanwe agbanwe (0-24 h, 22%) na mkpochapụ akụrụ nke fluconazole (0.124 ml / min / n'arọ) na ndị ọrịa meworo agadi dị ala karịa na ndị ọrịa na-eto eto.

Ngosipụta

A na-egosi Fluconazole maka ọgwụgwọ ọrịa ndị a na ndị okenye:

- maningitis nke cryptococcal;

- coccidioidomycosis;

- candidiasis na-egbu egbu;

- candidiasis mucous, gụnyere. oropharyngeal candidiasis, esophageal candidiasis, candidiasis na-adịghị ala ala mucocutaneous candidiasis;

- candidiasis atrophic na-adịghị ala ala nke oghere ọnụ (nke jikọtara ya na ịcha eze), mgbe ịdị ọcha ọnụ ma ọ bụ ọgwụgwọ mpaghara ezughị;

- candidiasis ikpu, nnukwu ma ọ bụ ugboro ugboro, mgbe ọgwụgwọ mpaghara adịghị etinye ya;

- candidal balanitis, mgbe ọgwụgwọ mpaghara adịghị emetụta;

- ntu dermatophytosis (onychomycosis), mgbe ọgwụgwọ na ọgwụ ndị ọzọ adịghị anabata;

- dermatomycosis, gụnyere. dermatophytosis nke ụkwụ, dermatophytosis nke ogwe, inguinal dermatophytosis, tinea versicolor na akpụkpọ candidiasis, mgbe egosi usoro ọgwụgwọ.

E gosipụtara Fluconazole maka mgbochi nke ọrịa ndị a na ndị okenye:

- nlọghachi azụ nke maningitis cryptococcal na ndị ọrịa nwere nnukwu ihe ize ndụ nke nlọghachi azụ;

- nlọghachi nke oropharyngeal candidiasis na esophageal candidiasis na ndị ọrịa bu nje HIV nwere nnukwu ihe ize ndụ nke nlọghachi azụ;

- iji belata ugboro ugboro nke nlọghachi nke candidiasis ikpu (4 ma ọ bụ karịa ngosipụta kwa afọ);

- maka igbochi ọrịa candidadal na ndị ọrịa nwere neuropenia ogologo oge (dịka ndị ọrịa nwere hemoblastoses na-anata kemoterapi ma ọ bụ ndị ọrịa na-ebugharị hematopoietic stem cell transplantation).

A na-egosi Fluconazole maka ọgwụgwọ ụmụaka.

A na-eji Fluconazole na-agwọ ọrịa mucosal candidiasis (oropharyngeal na esophageal candidiasis), candidiasis invasive, maningitis cryptococcal, na iji gbochie ọrịa candidadal na ndị ọrịa na-adịghị ahụkebe. Enwere ike iji Fluconazole dị ka ọgwụgwọ nlekọta iji gbochie nlọghachi nke maningitis cryptococcal na ụmụaka nwere nnukwu ihe ize ndụ nke ịlaghachi azụ.

Contraindications

hypersensitivity na fluconazole, akụkụ ndị ọzọ nke ọgwụ ma ọ bụ ihe azole nwere usoro yiri fluconazole;

nchịkwa nke terfenadine n'otu oge n'oge ojiji nke fluconazole ugboro ugboro na 400 mg / ụbọchị ma ọ bụ karịa (lee ngalaba "Mmekọrịta na ọgwụ ndị ọzọ");

- iji ọgwụ eme ihe n'otu oge na-abawanye oge QT ma metabolized site na iji CYP3A4 isoenzyme, dị ka cisapride, astemizole, erythromycin, pimozide, quinidine, amiodarone (lee ngalaba "Mmekọrịta na ọgwụ ndị ọzọ");

- ụmụaka ruo afọ 3.

Akpachara anya: ịba ọcha n'anya na / ma ọ bụ ụkọ akụrụ, ọdịdị nke ọkụ ọkụ n'oge iji fluconazole na ndị ọrịa nwere ọrịa fungal na-efe efe na ọrịa fungal na-efe efe / systemic, ojiji nke ọgwụ hepatotoxic nwere ike ime n'otu oge, ọnọdụ proarrhythmic na ndị ọrịa nwere ọtụtụ ihe ize ndụ. ọrịa obi na-arịa ọrịa obi, ahaghị nhata electrolyte, iji otu oge ọgwụ na-akpata arrhythmias), terfenadine na fluconazole n'otu oge na ihe na-erughị 400 mg / ụbọchị, ndị ọrịa nwere anabataghị acetylsalicylic acid, afọ ime, aṅụrụma.

Jiri n'oge ime na n'oge ara

Nnyocha nchekwa zuru oke na nke a na-achịkwa nke ọma banyere iji fluconazole na ụmụ nwanyị dị ime emebeghị.

A kọwawo ọtụtụ ọnọdụ nke ọtụtụ nkwarụ ọmụmụ na ụmụ amụrụ ọhụrụ ndị nne ha nwetara ọgwụgwọ fluconazole dị elu (400-800 mg / day) maka coccidioidomycosis maka ọtụtụ ma ọ bụ niile nke mbụ trimester. Achọpụtala ihe na-adịghị mma nke mmepe mmepe: brachycephaly, mmebi akụkụ ihu nke okpokoro isi, mmebi nke oghere cranial, mgbawa palate, curvature nke femur, mkparị na ịgbatị ọgịrịga, arthrogryposis na nkwarụ obi. Ka ọ dị ugbu a, ọ nweghị ihe akaebe nke njikọ nke anomalies congenital edepụtara na iji obere doses nke fluconazole (150 mg otu ugboro maka ọgwụgwọ nke vulvovaginal candidiasis) n'ime ọnwa mbụ nke afọ ime. N'oge ime ime, ekwesịrị izere iji fluconazole, belụsọ n'ọnọdụ ọrịa fungal siri ike na nke nwere ike ibute ndụ.

Ụmụ nwanyị ndị toruworo afọ ime kwesịrị iji ọgwụ mgbochi ime. A na-ahụ Fluconazole na mmiri ara ara na mkpokọta dị nso na plasma, yabụ akwadoghị iji ya mee ihe na ụmụ nwanyị n'oge a na-enye nwa ara.

Usoro onunu ogwu na nchịkwa

n'ime. A na-eloda capsules ahụ dum.

Enwere ike ịmalite ọgwụgwọ tupu enwee omenala na nsonaazụ ụlọ nyocha ndị ọzọ. Agbanyeghị, a ga-agbanwe ọgwụgwọ antifungal n'otu aka ahụ mgbe amapụtara nsonaazụ ọmụmụ ndị a. Mgbe ị na-ebufe onye ọrịa site na eriri afọ gaa na nchịkwa ọnụ nke ọgwụ, ma ọ bụ ọzọ, mgbanwe na dose kwa ụbọchị adịghị mkpa.

Usoro nke fluconazole kwa ụbọchị dabere na ọdịdị na ogo nke ọrịa fungal. Maka ọrịa na-achọ nchịkwa ugboro ugboro nke ọgwụ ahụ, ekwesịrị ịga n'ihu na ọgwụgwọ ruo mgbe mwepu nke ụlọ ọgwụ ma ọ bụ ụlọ nyocha nke ọrịa fungal na-arụ ọrụ. Ndị ọrịa AIDS na cryptococcal meningitis ma ọ bụ oropharyngeal candidiasis na-emekarị na-achọ ọgwụgwọ nlekọta iji gbochie nlọghachi nke ọrịa ahụ.

Jiri na ndị okenye

Site na meningitis cryptococcal na ọrịa cryptococcal nke mpaghara ndị ọzọ, a na-ejikarị ọgwụ ahụ eme ihe na 400 mg n'ụbọchị mbụ, mgbe ahụ, a na-aga n'ihu ọgwụgwọ na dose 200-400 mg otu ugboro kwa ụbọchị. Ogologo oge ọgwụgwọ maka ọrịa cryptococcal na-adabere na ọnụnọ nke mmetụta ahụike na mycological; na cryptococcal meningitis, a na-aga n'ihu na ọgwụgwọ ọ dịkarịa ala izu 6-8. N'ọnọdụ ọgwụgwọ nke ọrịa na-eyi ndụ egwu, enwere ike ịbawanye dose kwa ụbọchị ruo 800 mg. Maka mgbochi nke nlọghachite nke maningitis cryptococcal na ndị ọrịa nwere nnukwu ihe ize ndụ ịlaghachi azụ, mgbe emechara usoro ọgwụgwọ mbụ, enwere ike ịga n'ihu na ọgwụgwọ fluconazole na dose nke 200 mg / ụbọchị ruo ogologo oge.

Mgbe coccidioidomycosis nwere ike ịchọ iji ọgwụ ahụ na dose nke 200-400 mg / ụbọchị. Maka ụfọdụ ọrịa, ọkachasị ndị metụtara meninges, enwere ike ịtụle dose nke 800 mg / ụbọchị. A na-ekpebi oge ọgwụgwọ n'otu n'otu, ọ nwere ike ịdịru ruo afọ 2; ọ bụ ọnwa 11-24 maka coccidioidomycosis, ọnwa 2-17 maka paracoccidioidomycosis, ọnwa 1-16 maka sporotrichosis, na ọnwa 3-17 maka histoplasmosis.

Maka candidemia, nke a na-ekesa candidiasis na ọrịa ndị ọzọ na-efe efe na-efe efe, dose a na-ebu ibu bụ 800 mg n'ụbọchị mbụ, na-esote dose nke 400 mg / ụbọchị. Ogologo oge ọgwụgwọ dabere na nrụpụta ụlọ ọgwụ. Nkwenye n'ozuzu maka oge ọgwụgwọ maka candidemia bụ izu 2 mgbe omenala ọbara mbụ na-adịghị mma na mwepu nke ihe ịrịba ama na mgbaàmà nke candidemia.

Ọgwụgwọ nke mucous candidiasis

Maka candidiasis oropharyngeal, ntinye ntinye: 200-400 mg n'ụbọchị mbụ, ọgwụ na-esote: 100-200 mg otu ugboro n'ụbọchị maka ụbọchị 7-21. Ọ bụrụ na ọ dị mkpa, ndị ọrịa nwere mmechi siri ike nke ọrụ mgbochi ọrịa nwere ike ịga n'ihu ọgwụgwọ ruo ogologo oge.

Na candiduria, ọgwụ dị irè na-abụkarị 200-400 mg / ụbọchị yana oge ọgwụgwọ nke ụbọchị 7-21. N'ime ndị ọrịa nwere oke ọrụ sistemu ahụ ji alụso ọrịa ọgụ, enwere ike iji ọgwụgwọ ogologo oge.

Na candidiasis mucocutaneous na-adịghị ala ala, a na-eji 50-100 mg / ụbọchị maka ọgwụgwọ ruo ụbọchị 28. Dabere n'ịdị njọ nke ọrịa a na-agwọ ma ọ bụ nsogbu usoro ahụ ji alụso ọrịa ọgụ na ọrịa, enwere ike iji ọgwụgwọ ogologo oge mee ihe.

Maka candidiasis nke esophagus, a na-ebufe dose nke 200-400 mg n'ụbọchị mbụ, nke na-esote 100-200 mg kwa ụbọchị. Usoro ọgwụgwọ bụ ụbọchị 14-30 (rue mgbe a ga-enweta mgbaghara nke esophageal candidiasis). Ọ bụrụ na ọ dị mkpa, ndị ọrịa nwere mmechi siri ike nke ọrụ mgbochi ọrịa nwere ike ịga n'ihu ọgwụgwọ ruo ogologo oge.

Maka mgbochi nke nlọghachi nke oropharyngeal candidiasis na ndị ọrịa bu nje HIV nwere nnukwu ihe ize ndụ ịlaghachi azụ, a na-eji fluconazole na 100-200 mg kwa ụbọchị ma ọ bụ 200 mg ugboro 3 n'izu maka oge na-adịghị agwụ agwụ n'ime ndị ọrịa nwere mgbochi na-adịghị ala ala.

Iji gbochie nlọghachi nke candidiasis nke esophageal na ndị ọrịa bu nje HIV nwere nnukwu ihe ize ndụ ịlaghachi azụ, a na-eji fluconazole na 100-200 mg kwa ụbọchị ma ọ bụ 200 mg ugboro 3 n'izu maka oge na-adịghị agwụ agwụ na ndị ọrịa nwere mgbochi na-adịghị ala ala.

Na atrophic candidiasis na-adịghị ala ala nke oghere ọnụ nke jikọtara ya na iyi eze, a na-ejikarị ọgwụ ahụ eme ihe na 50 mg 1 oge kwa ụbọchị maka ụbọchị 14 yana ngwakọta na ndị na-ahụ maka antiseptik mpaghara maka ọgwụgwọ prosthesis.

Na nnukwu ikpu candidiasis, candiddal balanitis, fluconazole na-eji otu ugboro ọnụ na dose nke 150 mg. Iji belata ugboro nke nlọghachi nke candidiasis ikpu, a pụrụ iji ọgwụ ahụ na dose nke 150 mg kwa ụbọchị atọ - ngụkọta nke 3 doses (na 1st, 4th na 7th ụbọchị), mgbe ahụ, mmezi dose nke 150 mg otu ugboro. izu. Enwere ike iji dose mmezi ahụ ruo ọnwa isii.

Maka onychomycosis, ọgwụ akwadoro bụ 150 mg otu ugboro n'izu. A ga-aga n'ihu na ọgwụgwọ ruo mgbe dochie ntu nje (uto nke ntu na-enweghị ọrịa). Mmụba mbọ aka na mbọ aka na-ewekarị ọnwa 3-6 na ọnwa 6-12, n'otu n'otu. Agbanyeghị, ọnụego uto nwere ike ịdịgasị iche site na mmadụ gaa na onye yana kwa dịka afọ. Mgbe ọgwụgwọ na-aga nke ọma nke ọrịa na-adịghị ala ala na-adịte aka, a na-ahụ mgbanwe n'ụdị mbọ mgbe ụfọdụ.

Ọgwụgwọ dermatomycosis

Maka ọrịa anụ ahụ, gụnyere dermatophytosis nke ụkwụ, dermatophytosis nke ogwe osisi, ukwu dermatophytosis na ọrịa candidal, dose akwadoro bụ 150 mg otu ugboro kwa izu ma ọ bụ 50 mg otu ugboro kwa ụbọchị. Ogologo oge ọgwụgwọ na-abụkarị izu 2-4, yana mycoses nke ụkwụ, enwere ike ịchọ ọgwụgwọ ogologo oge ruo izu 6.

Na lichen nwere ọtụtụ agba, a na-atụ aro dose bụ 300-400 mg otu ugboro kwa izu maka izu 1-3. Usoro ọgwụgwọ ọzọ bụ iji ọgwụ 50 mg otu ugboro kwa ụbọchị maka izu 2-A.

Maka mgbochi nke candidiasis na ndị ọrịa nwere etuto ọjọọ, ọgwụ a na-atụ aro nke fluconazole bụ 200-400 mg otu ugboro kwa ụbọchị, dabere n'ihe ize ndụ nke ịmalite ọrịa fungal. Maka ndị ọrịa nwere nnukwu ihe ize ndụ nke ibute ọrịa zuru oke, dịka ọmụmaatụ, nwere neutropenia siri ike ma ọ bụ na-adịte aka, a na-atụ aro dose bụ 400 mg otu ugboro kwa ụbọchị. A na-eji Fluconazole ụbọchị ole na ole tupu mmepe nke neutropenia a na-atụ anya ya na, mgbe mmụba nke ọnụọgụ neutrophils karịrị 1000 mm3, a na-aga n'ihu na ọgwụgwọ maka ụbọchị 7 ọzọ.

Jiri na ụmụaka

Dị ka ọrịa ndị yiri ya na ndị okenye, oge ọgwụgwọ na-adabere na mmetụta ahụike na mycological. Maka ụmụaka, dose nke ọgwụ kwa ụbọchị ekwesịghị ịfe nke ahụ maka ndị okenye.


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